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Transcriptomic analysis and pathway validation To further elucidate the mechanism of EGCG-Zn, we performed transcriptome sequencing on rectal tissues from control (Control), irradiated (RT), and EGCG-Zn-treated mice
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Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival
Whether a local ferroptotic event expands into surrounding tissue remains strongly constrained by threshold behavior
(6) The results were compared to control wounds without intervention
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