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The research so far is promising, but more studies are needed to confirm findings and refine treatment protocols

Why do some people report weight gain instead

it is a structural feature of the literature that affects how much independent confirmation any given claim actually has

For people with genetic variants that cause more of an impact on CYP1B1 upregulation combined with an inability to eliminate the estrogen metabolites fast enough (due to phase II genes, diet, and lifestyle) then cigarette smoking is going to significantly increase the bad estrogen metabolites

For people following a plant-based diet that choose to exclude animal products, it can be difficult to get enough B12