Domestic preference rationale: Many researchers prefer domestic vendors despite potential cost premiums
[1] [2] According to NICE guideline NG28 (Type 2 diabetes in adults: management), GLP-1 receptor agonists may be considered when metformin is contraindicated or not tolerated, or when other treatments have not achieved adequate glycaemic control, particularly in patients with a BMI 35 kg/m (or lower in certain ethnic groups) or when weight loss would provide additional clinical benefit
The platforms are more alike than different
Among the other GLP1RA, semaglutide has superior evidence in terms of weight loss, with an average weight loss of 4.5 to 6.5 kg, as seen in the SUSTAIN trials at a dose of 1 mg
This ensures patients receive safe, effective treatment while maintaining appropriate medical oversight
It promotes physiological wellness through immunomodulationspecifically upregulating immunoglobulin (IgA) and macrophage activityand supports cardiovascular health via cholesterol metabolism (61)