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Central nervous system GLP-1 receptors are distributed throughout brain regions implicated in depression, including the hippocampus, prefrontal cortex, and nucleus accumbens

Polyagonists that combine several hormones achieve even more impressive results in the treatment of obesity and T2D

Understanding how these medications work helps explain why certain gastrointestinal symptoms may occur during treatment

In the UK, different GLP-1 receptor agonists have specific licensed indications: For type 2 diabetes : semaglutide (Ozempic), dulaglutide (Trulicity), and liraglutide (Victoza) For weight management : semaglutide 2.4mg (Wegovy) and liraglutide 3.0mg (Saxenda) NICE guideline NG28 recommends GLP-1 receptor agonists as treatment options for type 2 diabetes when first-line therapies have not achieved adequate glycaemic control

This modification enhances its biological activity, resulting in a higher affinity for the IGF-1 receptor and a lower affinity for IGF-binding proteins compared to endogenous IGF-1

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