The linkage of NAD + metabolism to the internal clocks is firstly evidenced by that the NAD(P) + /NAD(P)H ratio modulates the DNA-binding activity of the core oscillators, such as CLOCK: BMAL1 and NPAS2: BMAL1 heterodimers
Exp Toxicol Pathol 54(4):313318 Uygur R, Aktas C, Caglar V, Uygur E, Erdogan H, Ozen OA (2016) Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes
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