Abstract The glutathione (GSH) redox system plays a central role in maintaining cellular homeostasis, but its dysregulation in cancer contributes to tumor progression, therapy resistance, and metabolic adaptation
Moreover, two fusion proteins Gsh2-Gsh1 and Pro1-GshB were constructed to increase the two-step coupling efficiency of GSH synthesis by mimicking the native domain fusion of GshF
Although anti-cancer therapy targeting metabolism has achieved some gratifying results, it is still currently believed that this field has the following shortcomings for possible future breakthroughs: 1) The side effects of such drugs limit their clinical effects as the optimal dose window is hard to be determined
Evala estado nutricional basal ya que deficiencias de cofactores (selenio, vitamina C, glicina) limitan aprovechamiento del glutatin suplementario
Cul es el estatus regulatorio actual
10.1016/s0166-2236(99)01401-0 Trends Neurosci