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For instance, PAGln significantly alleviates doxorubicin-induced cardiac toxicity via gut microbial metabolism regulation, reverses abnormal myocardial gene expression (e.g., Klb, Ece2, Casq1), and mitigates myocardial injury and apoptosis through mechanisms involving lipid metabolism, calcium signaling pathways, and store-operated Ca 2+ channel activity (Huang et al., 2025)

Clinical research has shown that it significantly reduces liver enzyme levels in patients with non-alcoholic fatty liver disease

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Cytoskeleton 61 , 7482 (2005)

Introduction: Menopause, Hormones, and Oxidative Stress Menopause marks a significant transition in a womans life, typically between ages 45 and 55, as estrogen and progesterone levels decline