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Patients with longstanding diabetes (over 10 years) or poor prior glycemic control should undergo comprehensive dilated eye examination before starting GLP-1 medications to establish baseline retinal status

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showed in their study that, upon infection of mice engrafted with human immune cells carrying HLA-DR15+ or HLA-DR15- (DR4), EBV viral load and CD8 T cell expansion were higher in those HLA-DR15+ mice, and myelin basic protein-specific CD4 T cells were only detected in HLA-DR15+ mice (121, 122)