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The Bottom Line The shifting regulatory picture is potentially good news for patients who can benefit from carefully managed peptide therapy, depending on what the PCAC review concludes in July

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Semaglutide is not recommended during pregnancy or for women planning pregnancy in the near future

A 2024 double-blind RCT involving colonoscopic FMT found no significant motor improvement over six months despite stable engraftment profiles, whereas pooled analyses of small clinical cohorts (up to 100 + patients) show modest benefits in constipation, non-motor symptom burden, and quality of life [169]

10.1038/s41419-021-03687-8 Cell Death Dis