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Binding mechanism: Unlike peptides that bind to both the ECD and TMD, small-molecule agonists primarily interact with an allosteric binding site within the TMD

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Las alternativas incluyen cambiar a otro GLP-1, optimizar la dosis, terapia combinada con otros medicamentos, intervenciones intensivas de estilo de vida o ciruga baritrica en casos seleccionados

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& Wu, C

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doi: 10.1038/s41598-019-42517-y 9 AlvarezC

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The goal is to use the right tools for the right person

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doi:10.1016/j.neubiorev.2025.106159

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