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Most researchers don't maintain that discipline
No adverse or toxic events have been reported in healthy people who get too much B12 from food or supplements
The MHRA product information for hydroxocobalamin preparations lists several recognised side effects that patients should be aware of before commencing treatment
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J Mol Med
Those who follow a strict vegetarian or vegan diet without compensating with B12 fortified food for example ( vitamin B12 binds to animal proteins), or have low vitamin B12 levels due to a health condition that might affect vitamin B12 release and absorption, might have difficulty reaching their vitamin b12 requirements
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