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Early metabolic changes may include modest reductions in fasting blood glucose and decreased appetite

Brain mast cells are the first responders before microglia in the brain injuries since mast cells can release prestored mediators

Conversely, pharmaceutical GLP-1 medications remain more appropriate for certain situations: medically urgent conditions such as type 2 diabetes with poor control or obesity with serious health complications requiring rapid metabolic improvement

DOI: 10.3389/fphar.2014.00196

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