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Ageing Res Rev 89:101979

Three B vitamins are therefore essential for keeping homocysteine levels in check: Vitamin B12 (in the methionine synthase pathway) Folate (B9) (also in the methionine synthase pathway) Vitamin B6 (in the cystathionine beta-synthase pathway) When any of these three is low, the body cannot process homocysteine efficiently, and blood levels rise

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J Neurosci Res 79:240247 Bogaert YE, Sheu KF, Hof PR, Brown AM, Blass JP, Rosenthal RE, Fiskum G (2000) Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation

Adequate protein must then be ingested to induce optimal muscle hypertrophy in test subjects