The existence of a weak baseline IFN--dependent signal (104) leading to an inflammatory tone (105) seems essential to enable an effective anti-infectious response, just like engine warm up right before a car race
34 Exosomes are involved with angiogenesis, immune responses, cell adhesion and migration, inflammatory response, metabolic adaptation, fetal development, and intercellular communication
Int J Clin Exp Med (2015) 8:1816571
Similarly, higher iron accumulation has been seen in the brains of HD patients, and ferroptosis is shown to contribute to neuronal cell death in animal models of HD [10]
doi: 10.1523/eneuro.0123-18.2018 170
Neri S, Swinkels DW, Matlung HL, van Bruggen R