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In the SURMOUNT-1 trial, tirzepatide showed significant weight loss results in adults without diabetes over 72 weeks (15-21% body weight reduction, depending on dose), while orlistat typically produces more modest results (approximately 3-5% additional weight loss beyond placebo at 1 year)
This suggests that the medication treats the patient holistically rather than isolating a single symptom
Ongoing trials are recommended to assess long-term body mass changes after discontinuing semaglutide, which is important for understanding its lasting effects on weight management
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