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In addition, SGLT-2is can cause gluconeogenesis, which will counteract the glucose-lowering effect, whereas GLP-1RAs have the opposite effect on gluconeogenesis (Doumas et al., 2018)
doi:10.3390/brainsci13111503 174
Taking matters into ones own hands by playing with dose sizes is a gamble: It might reduce side effects or costs in the short term, but it could also render the treatment ineffective or introduce new risks, all for unverified benefits
55 ZhouF.ZouX.ZhangJ.WangZ.YangY.WangD
In my practice, I use lower doses than the maximum, combined with therapy, lifestyle changes, and attention to factors like inflammation and stress
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