When a drug is taken in therapeutic dosage, any toxic metabo-lite formed will be detoxified by normal enzymatic or non-enzymatic cellular defence mechanisms
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It is common to experience mild nausea or reduced appetite during the first few days after each increase, but these symptoms usually diminish within 12 weeks
Main similarities and differences in the effects of GLP-1 and GIP GIP and GLP-1 are incretin hormones with a common primary effect of stimulating insulin secretion in response to food intake, but with significant differences in additional physiological effects, particularly with regard to the regulation of glucagon secretion, effects on appetite and lipid metabolism, and bone metabolism