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The genes exemplified in Figure 4 comprise markers of inflammation and plaque stability that are associated with leukocyte recruitment (e.g., IL-1RN, IL-6, CCL2, OPN), leukocyte adhesion (SELE, VCAM-1), leukocyte extravasation, and plaque stability (e.g., MMP-3, MMP-13, CCL2), and plaque rupture and hemorrhage (CD163)
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2016;311:R36573
Unlike many other peptides, BPC-157 acts without binding to classic androgen or estrogen receptors, making it a unique subject for research into angiogenesis (blood vessel formation) and fibroblast migration