More than 50% of HEK cells overexpressing CEACAM5 turned completely spherical at 80 mOsm and remained swollen for at least 1hr without any regulatory volume decrease (48)
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Bu, T., Sun, Z., Pan, Y., Deng, X., & Yuan, G
VEGF, through binding to VEGF receptors (VEGFR), activates PI3K/AKT and MAPK/ERK pathways, which are vital for endothelial cell survival, migration, and proliferation
This dynamic character of the cellular metabolic network appears enhanced in cancer cells, in order to increase the adaptive phenotype and to maintain both viability and uncontrolled proliferation