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Sham mice received daily saline injections (2.5 mL/kg sc) and were used as controls
HRT does not typically affect thyroid function, but oral estrogen can increase thyroid-binding globulin levels, potentially altering thyroid medication requirements
Participants taking Foundayo, regardless of trial completion, lost an average of 25 pounds (11.1%), compared to 5.3 pounds (2.1%) with placebo
Alternative GLP-1 formulations, dose adjustments, or additional supportive medications may improve tolerability whilst maintaining the metabolic benefits of therapy
Proc Natl Acad Sci
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