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How GLP-1s Work And What That Means for Your Skin GLP-1 medications were originally developed to help people with type 2 diabetes help manage blood sugar, but they quickly became widely used for weight loss because of how they work

It improves fat metabolism, enhances insulin sensitivity, and appears to influence how the body partitions energy between fat storage and fat oxidation

Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

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Rybelsus (Semaglutide) is designed to be used by people with type 2 diabetes