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10.1038/tp.2015.68 64 Tang-ChristensenM.LarsenP

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7.3 Areas for further research Further studies assessing the implications of the glycemic and endocrine response to dietary protein for diabetes management could focus on: Responses and implications specifically for prediabetes The effects of protein in advanced T2D while on insulin sensitizers such as metformin The impact of protein quality/completeness on acute glycemic and hormonal response Rates of rebound hypoglycemia after rescue snacks of varying macromolecule content Classifying absorption rates of common protein sources More research into pre-exercise protein intake on preventing hypoglycemia Research to establish standardized protein doses for specific clinical scenarios in T1D, such as pre-bed snacks or pre-exercise supplementations Long-term randomized controlled trials examining the impact of replacing fast-digesting, BCAA-rich proteins with slow digesting proteins on insulin sensitivity in T2D Studies exploring the factors that predict interindividual variability in glycemic responses to different protein types More research into optimal AID system algorithms to account for meal composition Statements Author contributions SN: Writing original draft

Prolonged half-life of small-sized therapeutic protein using serum albumin-specific protein binder

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