3c, the hydroxyphenyl groups chelation site shifted from CuA to CuB, and it interacts more with regions L2 and L4, orienting from the L2 region towards CuB
These drugs are typically administered via weekly injection, though some formulations, like semaglutide, are now available in oral form and drug companies are actively working on oral forms for tirzepatide
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Food and Drug Administration): Pharmacy Compounding of Peptide Drug Products (Category 2 List - Safety concerns)
Science 336 , 12621267 (2012)