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If you take 1,000 to 3,000 mg of niacin daily, side effects can include diarrhea, nausea, heartburn, and abdominal pain

doi: 10.1016/j.ijcard.2011.09.039 260 McGuireDKShihWJCosentinoFCharbonnelBCherneyDZIDagogo-JackSet al

Based on information in: Chen Y., Liu L

The LactMed database, maintained by the National Library of Medicine, now states that tirzepatide is usually undetectable in breastmilk with subcutaneous doses of up to 5 mg and that absorption by the infant is unlikely because it is probably partially destroyed in the infant's gastrointestinal tract and poorly absorbed orally

2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Johnstone et al., 2016), the formation of such DNA adducts induces structural distortions of the DNA helix, which in turn leads to DNA damage, which activates multiple signaling pathways, one of which is the activation of the ATM-Chk2-p53 pathway (Benkafadar et al., 2017)