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Contraindications Use in patients with active peptic ulcer Patients with history of hypersensitivity to either of the drugs, Recent GI bleeding, Neonates Drug interaction Antagonizes the effects of furosemide & thiazides Pethidine & propanthelene reduce absorption of paracetamol Aspirin displaces ibuprofen from binding sites Increased risk of GI ulceration & bleeding when taken with anticoagulants Increases the risk of methotrexate toxicity & lithium toxicity when taken along Side effects Common (affecting between 1 in10 to 1 in 100) Constipation, Diarrhea, gas or bloating Dizziness, Nervousness Nausea Uncommon (affecting 1 in 100 to 1 in 1000) Ringing in the Ears Unexplained weight gain Fever, rashes, itching Swelling of the eyes, face, throat, arms, hands, feet, ankles, or lower legs Difficulty breathing or swallowing Loss of appetite Very rare (affecting less than 1 in 10,000) Yellowing of the skin or eyes Flu-like symptoms Fast heartbeat Cloudy, discolored, or bloody urine Difficult or painful urination Blurred vision, changes in color vision, o other vision problems Precautions Caution should be exercised in patients with asthma, especially in patients with frequent stuffed or runny nose or nasal polyps, swelling of the hands, arms, feet, ankles, or lower legs

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Homolya, L., Varadi, A

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Twenty-five histopathologically confirmed of oral cancer (OC) cases were enrolled into the second group

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