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SUSTAIN-6 Trial (Semaglutide) Semaglutide was shown to lower the risk of heart attack and stroke by 26% in high-risk patients

Lancet Diabetes Endocrinol 13(8):674684 Pv SG, Rada P, Valverde AM Cristina M

Side effects might include stomach upset, drowsiness, loss or gain of appetite, or irritation of the injection site

C-reactive protein level

While rebates may still be unavailable in 2027 for employers that cover GLP-1s only for obesity-related conditions but not for the broader weight loss indication, the potential impact may be smaller with a lower list price

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology