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[] In this pathway, adipocyte-derived leptin binds hypothalamic leptin receptor (LEPRb), activating Janus kinase 2signal transducer and activator of transcription 3 (JAK2STAT3) signaling to suppress appetite-promoting neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons while activating appetite-inhibiting proopiomelanocortin (POMC) neurons

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