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By supporting the structural matrix of the skin, collagen can help mitigate the appearance of fine lines and "crepey" skin that often accompany fat loss

Retatrutide is still investigational

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Because of the effects seen in animals, the FDA includes a warning with semaglutide just to be cautious, especially if you have a family history of thyroid issues

doi: 10.1056/NEJMoa2403347 257 WilcoxTDe BlockCSchwartzbardAZNewmanJD

Unlike earlier treatments that target a single receptor pathway, retatrutide engages three complementary hormonal signalling systems