These can include: Headaches Nausea Dizziness Tingling or numbness in extremities Flushing If you encounter any of these side effects, it is crucial to get in touch with your healthcare practitioner
It can be taken with other drugs and is non-habit-forming
It may also be prescribed for certain cobalt deficiencies, certain pancreatic diseases or intestinal malabsorption conditions
Glucagon suppression They inhibit glucagon release from pancreatic alpha cells, reducing hepatic glucose production
Pregnancy, certain gastrointestinal conditions, some medication combinations, and a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 require careful review
It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients