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Additionally, the surge in biotech and pharma investments targeting obesity has accelerated pipeline activity at this stage

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Tirzepatide and semaglutide have both been studied in pivotal trials for weight loss

Small observational studies have reported modest weight loss, but these typically lack adequate controls for dietary modification, exercise, and placebo effects

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UCP1 transcript abundance does not necessarily predict protein abundance, and protein abundance alone does not prove increased thermogenic flux