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Both genetic and environmental models demonstrate reduced taste receptor expression, especially in the hypothalamus and brainstem, but no significant changes in cortical or hippocampal expression (123)
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This has sparked a growing interest in exploring new treatments, including GLP-1 receptor agonists
From their beginnings as a treatment for type 2 diabetes, GLP-1 receptor agonists such as the semaglutide drugs Ozempic and Wegovy and the tirzepatide drugs Mounjaro and Zepbound have seen an explosion in use, most popularly for weight loss
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