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Dehydroascorbate is reduced to ascorbate by dehydroascorbate reductase (DHAR) at the expense of GSH, yielding oxidized glutathione (GSSG)

The three main mechanisms that glutathione exhibits in its action on hyperpigmentation include: Inhibition of tyrosinase activity is the main mechanism by which glutathione effectively lessens dark spots, patches, and uneven skin tone

Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder