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The reason for this may be that the cell cycle inhibitor p21 induces senescence in premature cells, a process called hit and run. VacA is regarded as double carcinogenesis considering that involves the activation of the ERK and Wnt signaling pathways and the upregulation of proto-oncogene expression along with the occurrence of defects in microtubule mitotic spindle formation through CagA/PAR1b
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It is a violation of this balance that leads to an increase in pressure, due to which the blood supply to the eye is impaired and the load on the optic nerve increases
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