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PYY-based compositions

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Unlike native GLP-1, GLP1-S has been structurally modified with amino acid substitutions and a fatty acid side chain, which promotes albumin binding

Cell (2008) 134(5):74356.10.1016/j.cell.2008.07.021 120 MartinonFChenXLeeAHGlimcherLH

Should Phase 3 trials demonstrate a favourable benefit-risk profile, Eli Lilly would be expected to submit a Marketing Authorisation Application (MAA) to the MHRA (and separately to the EMA for European markets) for regulatory review