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its activation directly enhances tricarboxylic acid (TCA) cycle flux and oxidative phosphorylation efficiency (Tavoulari et al., 2023

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This review highlights NAD+ as a central regulator of energy metabolism, mitochondrial function, and cellular repair, demonstrating that age-related declines in NAD+ may contribute to chronic disease, while supplementation with NAD+ boosters shows potential for reducing age-related decline and disease

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Triggered by upstream signals, the initiator caspases undergo autocleavage, and the subsequently activated cleaved initiator caspases stimulate the downstream executioner caspases to execute apoptosis (106)