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Extracellular IL-37 Promotes Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Activation of the PI3K/AKT Signaling Pathway

The mechanism of action is based on the stimulation of the glucagon-like peptide-1 receptor, which enhances insulin secretion, slows gastric emptying, and supports overall metabolic regulation

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In clinical trials, most patients experienced a significant reduction in stomach pain after the first few weeks of therapy