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Reactive oxygen species (ROS) act like sparks in a dry forest, igniting a blaze of tissue damage

Overloading with Active Ingredients More isn't always better

The patient data are presented in Table 1

This tipping point occurred between farnesyl-diphosphate farnesyltransferase 1 ( FDFT1 ), whose loss reduced Cryptosporidium growth and development of females, and squalene epoxidase ( SQLE ), the loss of which enhanced growth and the percentage of females

For example, NMR-titration experiments of non-glutathionylated poplar GrxC4 or ScGrx8 with GSH required high glutathione concentrations to detect chemical shifts 47,48 (and titrations of active site serine mutants with GSSG cannot discriminate between both glutathionyl moieties)

Holmes AS, Blaxill MF, Haley BE