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Any new or worsening symptoms while on therapy, including severe abdominal pain, persistent nausea or vomiting, or signs of gallbladder disease, require prompt medical evaluation

Practical Implications 1

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Melanocortin agonism stimulates melanocytes, and a related report describes eruptive nevi a sudden crop of new moles associated with an -MSH analog, exactly the kind of pigment-cell proliferation one would predict from over-stimulating this pathway

Many patients find that their stomach capacity has physically changed after being on a program, so you may still feel full faster than you did before starting treatment

Time dependence refers to the pattern of side effects being most prominent during treatment initiation and dose increases, then declining as the body adapts