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GLP-1RAs ,

They start with 0.75mg or even 1mg daily instead of building up from 0.25mg

Weight management A 2018 meta-analysis of randomized, placebo-controlled trials found that lipoic acid supplementation in those with high body mass index (BMI) resulted in significant, yet modest, reductions in weight (9 studies) and BMI (11 studies) in the absence of caloric restriction (except in one study) (105)

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Inhibiting System Xc- leads to decreased GSH levels, reduced GPX4 activity, and weakened cellular antioxidant capacity, promoting ferroptosis (Li FJ