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Lifestyle modifications should always be the foundation of any weight management plan
Rosenstock J, Guerci B, Hanefeld M, et al
Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons
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In the combination study with semaglutide (CagriSema), adding the amylin axis to the GLP-1 axis produced greater body-weight reduction than either molecule alone
When NNMT is overactive (common in obesity), cells struggle with energy production and metabolic efficiency
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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