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Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes

Factors such as cost savings, convenience, absorption issues, potential digestion, and comfort with self-administering injections can affect patients preferences

PMCID: PMC4613933

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One of the active forms of cobalamin, methylcobalamin, serves as a cofactor for methionine synthase, facilitating the conversion of homocysteine to methionine (20, 25, 72, 73)