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GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

Rall LB, Pictet RL, Williams RH, Rutter WJ

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Topiramate may be used long-term as well, especially when tolerated well

According to the Centers for Disease Control and Prevention (CDC), early signs such as vomiting and fatigue develop within hours, while severe cases progress to jaundice, confusion, and multi-organ failure if untreated