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Glutamate-mediated prolonged NMDAR and CP-AMPAR activation triggers a wide variety of intracellular events, that in turn initiate processes of Ca 2+ -mediated excitotoxicity and apoptosis (Zhu et al., 2000

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Below, we examine key mechanisms underlying neuronal degeneration, highlighting how they drive cellular damage (Figure 1)

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Also, those who have genetic defects often face L-Carnitine deficiency