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In the 1920s, the first studies to elucidate the mechanism of action of sclerosing agents were performed using the dorsal vein of the rabbit ear

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The individual studies, published in Cephalgia in 2010, and the pooled results, published in Headache in 2010, both showed a significant decrease in the number of headache days (per 28 days) with eight to nine fewer headache days at 24 weeks as well as a significant improvement in quality of life in the Botox group

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