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In addition to neural connections, the central clock system also synchronizes the circadian rhythms of the peripheral clock system through hormones or factors, such as arginine vasopressin (AVP) and tumor necrosis factor (TNF) ( FIGURE 1 The clock system mainly regulates metabolism in the following three ways

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doi:10.1016/S0076-6879(71)18006-8

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The condition affects roughly 1 to 3% of the general adult population, with peak incidence occurring between ages 30 and 50