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Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration
The frequency of the 100 mcg B12 injection then becomes once a month
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The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications
Can vitamin B12 injections be self-administered
Some protocols call for a one-month break every two months of use
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