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* Additional details on other secondary outcomes other than the change in body weight can be found at as NCT03954834 (SURPASS-1), NCT03987919 (SURPASS-2), NCT03882970 (SURPASS-3), NCT03730662 (SURPASS-4), NCT04039503 (SURPASS-5), NCT04537923 (SURPASS-6), NCT04255433 (SURPASS-CVOT), NCT03861052(SURPASS J-mono), NCT04093752 (SURPASS-AP-Combo), and NCT04184622 (SURMOUNT-1)