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[note 16] [175] Toxicity In rodents and primates, sufficiently high doses of amphetamine cause dopaminergic neurotoxicity, or damage to dopamine neurons, which is characterized by dopamine terminal degeneration and reduced transporter and receptor function

[PMID: 7263094] PubMed record related to this compound for laboratory literature review

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TLC-2716, developed based on this generation of LXR inverse agonists, has not been evaluated in humans, nor has any other compound of its kind 19,29