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Tirzepatide begins working on a similar timeline to semaglutide, with some patients reporting appetite changes almost immediately and significant weight changes becoming visible by weeks six through twelve

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Age also played a role, with the largest reductions in triptan use seen in younger adults aged 18 to 35

14 Individuals were followed for six months after the index prescription to ensure continuous exposure to either GLP-1RA medications or insulin

Individuals with obesity participating in a clinical trial of Wegovy safely lost 15% or more of their body weight, with similar results for other medications like Zepbound

Tier 3 requires a BMI of 27 or higher with prediabetes (or another Tier 3 condition), and a BMI of 31 meets that floor