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Ahmed AR, Rickards G, Coniglio D, Xia Y, Johnson J, Boss T, et al
Sulforaphane rescued rotenone-induced oxidative damage by activating the Nrf2 pathway ROS generation is a necessary by-product of oxidative metabolism and is tightly regulated in cells by various oxidant and antioxidant enzymes 39
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And as established in the previous section, it plays an active role in neuronal energy metabolism and mitochondrial function
Similarly, animals with deficiencies in indirect scavengers of ROS, such as sulfiredoxin and metallothionein, are highly susceptible to alcohol-induced hepatic injury 27,31
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